Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?

Robert C. Fang, Zol B. Kryger, Donald W. Buck, Mauricio De La Garza, Robert D Galiano, Thomas A. Mustoe

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Murine models have provided valuable insights into the pathogenesis of both diabetes and chronic wounds. However, only a few published reports to date have investigated wound healing differences among the differing diabetic mouse models. The goal of the present study was to further define the wound healing deficiency phenotypes of streptozotocin-induced (STZ-induced), Akita, and db/db diabetic mice in comparison with a promising new polygenic strain of Type 2 diabetes (NONcNZO10) by using three specific wound models that targeted different critical processes in the pathogenesis of chronic wounds. Incisional, excisional, and ischemia/reperfusion wound models were established on mice of each strain. Wound healing parameters including tensile strength, epithelial gap, and wound necrosis were evaluated. In contrast to the other diabetic mice, the NONcNZO10 strain was found to have significant wound healing impairments in all wound healing models. Not only do the NONcNZO10 mice appear to better model human Type 2 diabetes, these provocative findings suggest that the mice may show more clinically relevant wound healing deficiencies than previous diabetic mouse models.

Original languageEnglish (US)
Pages (from-to)605-613
Number of pages9
JournalWound Repair and Regeneration
Volume18
Issue number6
DOIs
StatePublished - Nov 1 2010

ASJC Scopus subject areas

  • Dermatology
  • Surgery

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