Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment

Kevin Robertson; Alan Landay; Sachiko Miyahara; Alyssa Vecchio; Mary Clare Masters; Todd T. Brown; Babafemi O. Taiwo

doi:10.1007/s13365-019-00795-2

Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment

Kevin Robertson, Alan Landay, Sachiko Miyahara, Alyssa Vecchio, Mary Clare Masters, Todd T. Brown, Babafemi O. Taiwo^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The AIDS Clinical Trials Group (ACTG) study A5303 investigated the associations between neuropsychological performance (NP) and inflammatory biomarkers in HIV-infected participants. Fifteen NP tests were administered at baseline and week 48 to 233 ART naïve participants randomized to maraviroc- or tenofovir-containing ART. Neurocognition correlated modestly with markers of lymphocyte activation and inflammation pre-ART (percent CD38+/HLA-DR+(CD4+) (r = − 0.22, p = 0.02) and percent CD38+/HLA-DR+(CD8+) (r = − 0.25, p = 0.02)), and with some monocyte subsets during ART (r = 0.25, p = 0.02). Higher interleukin-6 and percent CD38+/HLA-DR+(CD8+) were independently associated with worse severity of HIV-associated neurocognitive disorders (HAND) (p = 0.04 and 0.01, respectively). More studies to identify HAND biomarkers are needed.

Original language	English (US)
Pages (from-to)	107-113
Number of pages	7
Journal	Journal of neurovirology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s13365-019-00795-2
State	Published - Feb 1 2020

Keywords

Antiretroviral therapy
Biomarker
Inflammation
Monocytes
Neurocognitive performance

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13365-019-00795-2

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title = "Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment",

abstract = "The AIDS Clinical Trials Group (ACTG) study A5303 investigated the associations between neuropsychological performance (NP) and inflammatory biomarkers in HIV-infected participants. Fifteen NP tests were administered at baseline and week 48 to 233 ART na{\"i}ve participants randomized to maraviroc- or tenofovir-containing ART. Neurocognition correlated modestly with markers of lymphocyte activation and inflammation pre-ART (percent CD38+/HLA-DR+(CD4+) (r = − 0.22, p = 0.02) and percent CD38+/HLA-DR+(CD8+) (r = − 0.25, p = 0.02)), and with some monocyte subsets during ART (r = 0.25, p = 0.02). Higher interleukin-6 and percent CD38+/HLA-DR+(CD8+) were independently associated with worse severity of HIV-associated neurocognitive disorders (HAND) (p = 0.04 and 0.01, respectively). More studies to identify HAND biomarkers are needed.",

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author = "Kevin Robertson and Alan Landay and Sachiko Miyahara and Alyssa Vecchio and Masters, {Mary Clare} and Brown, {Todd T.} and Taiwo, {Babafemi O.}",

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AU - Landay, Alan

AU - Miyahara, Sachiko

AU - Vecchio, Alyssa

AU - Masters, Mary Clare

AU - Brown, Todd T.

AU - Taiwo, Babafemi O.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - The AIDS Clinical Trials Group (ACTG) study A5303 investigated the associations between neuropsychological performance (NP) and inflammatory biomarkers in HIV-infected participants. Fifteen NP tests were administered at baseline and week 48 to 233 ART naïve participants randomized to maraviroc- or tenofovir-containing ART. Neurocognition correlated modestly with markers of lymphocyte activation and inflammation pre-ART (percent CD38+/HLA-DR+(CD4+) (r = − 0.22, p = 0.02) and percent CD38+/HLA-DR+(CD8+) (r = − 0.25, p = 0.02)), and with some monocyte subsets during ART (r = 0.25, p = 0.02). Higher interleukin-6 and percent CD38+/HLA-DR+(CD8+) were independently associated with worse severity of HIV-associated neurocognitive disorders (HAND) (p = 0.04 and 0.01, respectively). More studies to identify HAND biomarkers are needed.

AB - The AIDS Clinical Trials Group (ACTG) study A5303 investigated the associations between neuropsychological performance (NP) and inflammatory biomarkers in HIV-infected participants. Fifteen NP tests were administered at baseline and week 48 to 233 ART naïve participants randomized to maraviroc- or tenofovir-containing ART. Neurocognition correlated modestly with markers of lymphocyte activation and inflammation pre-ART (percent CD38+/HLA-DR+(CD4+) (r = − 0.22, p = 0.02) and percent CD38+/HLA-DR+(CD8+) (r = − 0.25, p = 0.02)), and with some monocyte subsets during ART (r = 0.25, p = 0.02). Higher interleukin-6 and percent CD38+/HLA-DR+(CD8+) were independently associated with worse severity of HIV-associated neurocognitive disorders (HAND) (p = 0.04 and 0.01, respectively). More studies to identify HAND biomarkers are needed.

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Limited correlation between systemic biomarkers and neurocognitive performance before and during HIV treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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