Linezolid versus vancomycin for treatment of resistant Gram-positive infections in children

Sheldon L. Kaplan*, Jaime G. Deville, Ram Yogev, Ma Rayo Morfin, Elba Wu, Stuart Adler, Barbara Edge-Padbury, Sharon Naberhuis-Stehouwer, Jon B. Bruss

*Corresponding author for this work

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

Background. Pediatric infections caused by resistant Gram-positive infections are an increasing concern with limited treatment options. Linezolid, a new oxazolidinone, is active against staphylococci, streptococci and enterococci. Objective. To assess clinical efficacy and safety of linezolid vs. vancomycin in antibiotic-resistant Gram-positive infections in children. Design. Hospitalized children (birth to 12 years of age) with nosocomial pneumonia, complicated skin/skin structure infections, catheter-related bacteremia, bacteremia of unknown source or other infections caused by Gram-positive bacteria were randomized 2:1 to receive linezolid intravenously followed by oral linezolid or vancomycin and then by an appropriate oral agent. Treatment duration was 10 to 28 days. Results. There were 321 patients enrolled (linezolid 219, vancomycin 102). Clinical cure rates were 79% vs. 74% (P = 0.36) and 89% vs. 85% (P = 0.31) for linezolid and vancomycin in intent-to-treat and clinically evaluable patients, respectively. Cure rates were similar by age and infection diagnosis. Pathogen eradication rates in microbiologically evaluable patients were high for linezolid and vancomycin, respectively, for methicillin-susceptible S. aureus (95% vs. 94%; P = 0.82), methicillin-resistant S. aureus (88% vs. 90%; P = 0.89) and methicillin-resistant coagulase-negative staphylococci (85% vs. 83%, P = 0.87). In clinically evaluable patients, linezolid-treated patients required significantly fewer days of intravenous therapy compared with vancomycin-treated patients (8.0 ± 4.8; 10.9 ± 5.8 days, respectively; P < 0.001). In addition significantly fewer linezolid-treated patients had drug-related adverse events than did vancomycin-treated patients (19% vs. 34%, respectively; P = 0.003). Hematologic events were uncommon and similar between treatment groups. Conclusions. Linezolid was well-tolerated and as effective as vancomycin in treating serious Gram-positive infections in children.

Original languageEnglish (US)
Pages (from-to)677-685
Number of pages9
JournalPediatric Infectious Disease Journal
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2003

Keywords

  • Antimicrobial resistance
  • Clinical trial
  • Gram-positive
  • Linezolid
  • Methicillin-resistant Staphylococcus aureus
  • Pediatrics
  • Vancomycin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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    Kaplan, S. L., Deville, J. G., Yogev, R., Morfin, M. R., Wu, E., Adler, S., Edge-Padbury, B., Naberhuis-Stehouwer, S., & Bruss, J. B. (2003). Linezolid versus vancomycin for treatment of resistant Gram-positive infections in children. Pediatric Infectious Disease Journal, 22(8), 677-685. https://doi.org/10.1097/01.inf.0000078160.29072.42