Linguistic processing during repetitive transcranial magnetic stimulation

S. S. Flitman, J. Grafman*, E. M. Wassermann, V. Cooper, J. O'Grady, A. Pascual-Leone, M. Hallett

*Corresponding author for this work

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

To determine if linguistic processing could be selectively disrupted with repetitive transcranial magnetic stimulation (rTMS), rTMS was performed during a picture-word verification task. Seven right-handed subjects were trained in two conditions: picture-word verification, which required the subject to verify whether the picture of an object matched the subtitle name on the same page, and frame verification, which required subjects to verify whether there was a rectangular frame around the combined object picture and subtitle. Half of the trials were performed during rTMS. The effects of rTMS on performance were evaluated at the following four scalp positions: left anterior (the area where rTMS produced speech arrest), a mirror site on the right, and two positions in the left and right parietal region. Stimulation over the left deltoid muscle served as a control. Subjects had less difficulty in making picture-word matching decisions during unstimulated compared with stimulated trials at the left anterior and posterior positions. No significant difference in accuracy was detected in the frame verification condition, but response times in the frame verification condition were longer with stimulation at the left anterior position. Because rTMS of the dominant hemisphere affected linguistic processing independent of speech motor output, we confirm that rTMS may be used to investigate language and other cognitive functions.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalNeurology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 1998

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Transcranial Magnetic Stimulation
Linguistics
Deltoid Muscle
Parietal Lobe
Scalp
Cognition
Reaction Time
Names
Language

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Flitman, S. S., Grafman, J., Wassermann, E. M., Cooper, V., O'Grady, J., Pascual-Leone, A., & Hallett, M. (1998). Linguistic processing during repetitive transcranial magnetic stimulation. Neurology, 50(1), 175-181. https://doi.org/10.1212/WNL.50.1.175
Flitman, S. S. ; Grafman, J. ; Wassermann, E. M. ; Cooper, V. ; O'Grady, J. ; Pascual-Leone, A. ; Hallett, M. / Linguistic processing during repetitive transcranial magnetic stimulation. In: Neurology. 1998 ; Vol. 50, No. 1. pp. 175-181.
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Flitman, SS, Grafman, J, Wassermann, EM, Cooper, V, O'Grady, J, Pascual-Leone, A & Hallett, M 1998, 'Linguistic processing during repetitive transcranial magnetic stimulation', Neurology, vol. 50, no. 1, pp. 175-181. https://doi.org/10.1212/WNL.50.1.175

Linguistic processing during repetitive transcranial magnetic stimulation. / Flitman, S. S.; Grafman, J.; Wassermann, E. M.; Cooper, V.; O'Grady, J.; Pascual-Leone, A.; Hallett, M.

In: Neurology, Vol. 50, No. 1, 01.01.1998, p. 175-181.

Research output: Contribution to journalArticle

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Flitman SS, Grafman J, Wassermann EM, Cooper V, O'Grady J, Pascual-Leone A et al. Linguistic processing during repetitive transcranial magnetic stimulation. Neurology. 1998 Jan 1;50(1):175-181. https://doi.org/10.1212/WNL.50.1.175