The Opitz GBBB syndrome (OS) is characterized in part by widely spaced inner ocular canthi and hypospadias. Recently, linkage analysis showed that the gene for the X-linked form to be located in an 18 cM region spanning Xp22. We have now conducted linkage analysis in a family previously published as having the BBB syndrome and found tight linkage to DXS7104 (Z=3.3, θ=0.0). Our data narrows the candidate region to 4 cM and should facilitate the identification and characterization of one of the genes involved in midline development.
|Original language||English (US)|
|Number of pages||5|
|Journal||American Journal of Medical Genetics|
|State||Published - Jan 20 1997|
- GBBB syndrome
- Opitz syndrome
ASJC Scopus subject areas