@article{5e3f2c7de7b0410cb22ac1fd1858cdd6,
title = "Lipidomic response to coffee consumption",
abstract = "Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. Our objective was to identify individual lipid changes in response to coffee drinking. We profiled the lipidome of fasting serum samples collected from a previously reported single blinded, three-stage clinical trial. Forty-seven habitual coffee consumers refrained from drinking coffee for 1 month, consumed 4 cups of coffee/day in the second month and 8 cups/day in the third month. Samples collected after each coffee stage were subject to quantitative lipidomic profiling using ion-mobility spectrometry–mass spectrometry. A total of 853 lipid species mapping to 14 lipid classes were included for univariate analysis. Three lysophosphatidylcholine (LPC) species including LPC (20:4), LPC (22:1) and LPC (22:2), significantly decreased after coffee intake (p < 0.05 and q < 0.05). An additional 72 species mapping to the LPC, free fatty acid, phosphatidylcholine, cholesteryl ester and triacylglycerol classes of lipids were nominally associated with coffee intake (p < 0.05 and q > 0.05); 58 of these decreased after coffee intake. In conclusion, coffee intake leads to lower levels of specific LPC species with potential impacts on glycerophospholipid metabolism more generally.",
keywords = "Biomarkers, Caffeine, Coffee, Lipidomics, Lipids, Lysophosphatidylcholine, Trial",
author = "Alan Kuang and Iris Erlund and Christian Herder and Westerhuis, {Johan A.} and Jaakko Tuomilehto and Cornelis, {Marilyn C.}",
note = "Funding Information: Acknowledgments: We thank Paulig Oy, Helsinki, Finland for the donation of coffee for this trial. Matlab computations in this paper were run on the Quest cluster supported in part through the computational resources and staff contributions provided for the Quest high performance computing facility at Northwestern University, which is jointly supported by the Office of the Provost, the Office for Research, and Northwestern University Information Technology. Funding Information: Funding: This work was supported by the American Diabetes Association (ADA, 7-13-JF-15 to MCC). The original trial was supported by a grant from the Institute of Scientific Information on Coffee, which is a consortium of major European Coffee Companies (JT). The German Diabetes Center was supported by the Ministry of Culture and Science of the State of North Rhine-Westphalia (MKW NRW), the German Federal Ministry of Health (BMG) and in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD). Funding Information: This work was supported by the American Diabetes Association (ADA, 7-13-JF-15 to MCC). The original trial was supported by a grant from the Institute of Scientific Information on Coffee, which is a consortium of major European Coffee Companies (JT). The German Diabetes Center was supported by the Ministry of Culture and Science of the State of North Rhine-Westphalia (MKW NRW), the German Federal Ministry of Health (BMG) and in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD). Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = dec,
doi = "10.3390/nu10121851",
language = "English (US)",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}