Lipoatrophic panniculitis: Case report and review of the literature

Lisa Y. Shen, M. Bruce Edmonson, Gary P. Williams, Chethana Chandrupatla Gottam, Molly A. Hinshaw, Joyce M. Teng

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: Lipoatrophic panniculitis (LP) is a rare disease of childhood characterized by eruption of tender erythematous nodules and plaques followed by circumferential bands of lipoatrophy often seen on the arms and legs. This condition has also been known as lipophagic panniculitis of childhood, annular atrophy of the ankles, and partial lipodystrophy. Observations: A previously healthy 8-year-old boy was evaluated for tender, raised plaques on the ankles, which progressed to circumferential atrophy of the distal lower extremities. Biopsy specimen analysis revealed a dense mixed infiltrate extending into the subcutaneous tissue as well as lipophages within the fatty lobules. A diagnosis of LP was made, and the patient began treatment with prednisone and hydroxychloroquine. Methotrexate was added later to the regimen as a steroid-sparing agent, and the dose was increased over the course of 3 months, by which time the cutaneous disease progression was nearly halted. However, the patient continued to have lower leg pain with bone changes demonstrated on magnetic resonance imaging. Conclusions: We report this case and review of the literature to call attention to the clinical features of LP and its association with skeletal changes. Our patient's response to combination therapy is of interest and contributes to the limited literature about management of this disease.

Original languageEnglish (US)
Pages (from-to)877-881
Number of pages5
JournalArchives of Dermatology
Issue number8
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Lipoatrophic panniculitis: Case report and review of the literature'. Together they form a unique fingerprint.

Cite this