Lipoprotein-associated phospholipase A2 and risk of incident peripheral arterial disease in a multi-ethnic cohort: The Multi-Ethnic Study of Atherosclerosis

Parveen K. Garg*, Neal W. Jorgensen, Robyn L. McClelland, Nancy S. Jenny, Michael H. Criqui, Matthew A. Allison, Philip Greenland, Robert S. Rosenson, David S. Siscovick, Mary Cushman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Prospective studies supporting a relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) and incident peripheral arterial disease (PAD) are limited. We evaluated the association of Lp-PLA2 with incident PAD in a multi-ethnic cohort without clinical cardiovascular disease. A total of 4622 participants with measurement of Lp-PLA2 mass and Lp-PLA2 activity and an ankle-brachial index (ABI) between 0.9 and 1.4 were followed for the development of PAD (median follow-up = 9.3 years), defined as an ABI ≤0.9 and decline from baseline ≥0.15. There were 158 incident PAD events during follow-up. In adjusted logistic regression models, each higher standard deviation of both Lp-PLA2 activity and mass did not confer an increased risk of developing PAD [odds ratios, (95% confidence intervals)]: 0.92 (0.66-1.27) for Lp-PLA2 activity and 1.06 (0.85-1.34) for mass. Additionally, no significant interaction was found according to ethnicity: p=0.43 for Lp-PLA2 activity and p=0.55 for Lp-PLA2 mass. We found no evidence of an association between Lp-PLA2 and incident PAD.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalVascular Medicine (United Kingdom)
Volume22
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • ankle-brachial index
  • inflammation
  • lipoprotein-associated phospholipase A
  • peripheral arterial disease (PAD)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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