TY - JOUR
T1 - Lipoproteins and lipoprotein mimetics for imaging and drug delivery
AU - Thaxton, C. Shad
AU - Rink, Jonathan S.
AU - Naha, Pratap C.
AU - Cormode, David P.
N1 - Funding Information:
This work was supported by NIH grants R01HL131557 , R00EB012165 and R03CA171661 , as well as by start-up funding from the University of Pennsylvania (all D.P.C.). J.S.R. thanks the National Institutes of Health and National Heart, Lung, and Blood Institute for a Vascular Surgery Scientist Training Program grant ( T32HL094293 ). C.S.T. thanks the Howard Hughes Medical Institute (HHMI) for a Physician Scientist Early Career Award , the Department of Defense / Air Force Office of Scientific Research ( FA95501310192 ), and the National Institutes of Health / National Cancer Institute ( U54CA151880 and R01CA167041 ).
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Lipoproteins are a set of natural nanoparticles whose main role is the transport of fats within the body. While much work has been done to develop synthetic nanocarriers to deliver drugs or contrast media, natural nanoparticles such as lipoproteins represent appealing alternatives. Lipoproteins are biocompatible, biodegradable, non-immunogenic and are naturally targeted to some disease sites. Lipoproteins can be modified to act as contrast agents in many ways, such as by insertion of gold cores to provide contrast for computed tomography. They can be loaded with drugs, nucleic acids, photosensitizers or boron to act as therapeutics. Attachment of ligands can re-route lipoproteins to new targets. These attributes render lipoproteins attractive and versatile delivery vehicles. In this review we will provide background on lipoproteins, then survey their roles as contrast agents, in drug and nucleic acid delivery, as well as in photodynamic therapy and boron neutron capture therapy.
AB - Lipoproteins are a set of natural nanoparticles whose main role is the transport of fats within the body. While much work has been done to develop synthetic nanocarriers to deliver drugs or contrast media, natural nanoparticles such as lipoproteins represent appealing alternatives. Lipoproteins are biocompatible, biodegradable, non-immunogenic and are naturally targeted to some disease sites. Lipoproteins can be modified to act as contrast agents in many ways, such as by insertion of gold cores to provide contrast for computed tomography. They can be loaded with drugs, nucleic acids, photosensitizers or boron to act as therapeutics. Attachment of ligands can re-route lipoproteins to new targets. These attributes render lipoproteins attractive and versatile delivery vehicles. In this review we will provide background on lipoproteins, then survey their roles as contrast agents, in drug and nucleic acid delivery, as well as in photodynamic therapy and boron neutron capture therapy.
KW - Computed tomography
KW - Drug delivery
KW - Fluorescence imaging
KW - High-density lipoprotein
KW - Low-density lipoprotein
KW - MRI
KW - Photodynamic therapy
KW - siRNA
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U2 - 10.1016/j.addr.2016.04.020
DO - 10.1016/j.addr.2016.04.020
M3 - Review article
C2 - 27133387
AN - SCOPUS:84966628837
VL - 106
SP - 116
EP - 131
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -