Liposomal spherical nucleic acids

Resham J. Banga, Natalia Chernyak, Suguna P. Narayan, Sonbinh T. Nguyen*, Chad A. Mirkin

*Corresponding author for this work

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3- phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells.

Original languageEnglish (US)
Pages (from-to)9866-9869
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number28
DOIs
StatePublished - Jul 16 2014

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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