Liposomal spherical nucleic acids

Resham J. Banga; Natalia Chernyak; Suguna P. Narayan; Sonbinh T. Nguyen; Chad A. Mirkin

doi:10.1021/ja504845f

Liposomal spherical nucleic acids

Resham J. Banga, Natalia Chernyak, Suguna P. Narayan, Sonbinh T. Nguyen^*, Chad A. Mirkin

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3- phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells.

Original language	English (US)
Pages (from-to)	9866-9869
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	136
Issue number	28
DOIs	https://doi.org/10.1021/ja504845f
State	Published - Jul 16 2014

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ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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AU - Banga, Resham J.

AU - Chernyak, Natalia

AU - Narayan, Suguna P.

AU - Nguyen, Sonbinh T.

AU - Mirkin, Chad A.

PY - 2014/7/16

Y1 - 2014/7/16

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AB - A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3- phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into the phospholipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells.

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Liposomal spherical nucleic acids

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