Lipoxin A4 protects against lipopolysaccharide-induced sepsis by promoting innate response activator B cells generation

Qiong Cheng, Zheng Wang, Ruihua Ma, Yongtao Chen, Yan Yan, Shuo Miao, Jingyu Jiao, Xue Cheng, Lingfei Kong, Duyun Ye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Sepsis is a serious disease that leads to severe inflammation, dysregulation of immune system, multi-organ failure and death. Innate response activator (IRA) B cells, which produce granulocyte-macrophage colony-stimulating factor (GM-CSF), protect against microbial sepsis. Lipid mediator lipoxin A4 (LXA4) exerts anti-inflammatory and immunoregulatory effects, and it has been reported that LXA4 receptor ALX/FPR2 is expressed on B cells. Here, we investigated the potential role of LXA4 on IRA B cells in lipopolysaccharide (LPS)-induced sepsis. We found that LXA4 significantly promoted the expansion of splenic IRA B cells and increased GM-CSF expression in splenic B cells with LPS stimulation. After splenectomy, LXA4 treatment did not change the serum or peritoneal IL-1β, IL-6 and TNF-α levels in LPS-induced sepsis. LXA4 accelerated the migration of peritoneal B cells to spleen for their differentiation into IRA B cells, whereas this effect was independent of peritoneal macrophage. Furthermore, LXA4 enhanced the phosphorylation level of signal transducer and activator of transcription 5 (STAT5) in splenic B cells. These results suggest that LXA4 protects against LPS-induced sepsis by promoting the generation and migration of splenic IRA B cells, and the underlying molecular mechanism may be related to STAT5 activation. It might provide new insights and therapeutic approaches for treating sepsis.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalInternational Immunopharmacology
StatePublished - Oct 1 2016


  • B cells
  • Granulocyte-macrophage colony-stimulating factor
  • Lipoxin A4
  • Sepsis
  • Signal transducer and activator of transcription 5

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


Dive into the research topics of 'Lipoxin A4 protects against lipopolysaccharide-induced sepsis by promoting innate response activator B cells generation'. Together they form a unique fingerprint.

Cite this