Lithium-associated kidney microcysts

Jennifer A Tuazon, David Casalino, Ehteshamuddin Syed, Daniel Batlle*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Long-term lithium therapy is associated with impairment in concentrating ability and, occasionally, progression to advanced chronic kidney disease from tubulointerstitial nephropathy. Biopsy findings in patients with lithium-induced chronic tubulointerstitial nephropathy include tubular atrophy and interstitial fibrosis interspersed with tubular cysts and dilatations. Recent studies have shown that cysts are seen in 33-62.5% of the patients undergoing lithium therapy. MR imaging is highly capable of defining renal morphological features and has been demonstrated to be superior to US and CT scan for the visualization of small renal cysts. The microcysts are found in both cortex and medulla, particularly in the regions with extensive atrophy and fibrosis, and can be multiple and bilateral. They tend to be sparse and do not normally exceed 1-2 mm in diameter. The renal microcysts in the image here reported are subtle, but consistent with lithium-induced chronic nephropathy. An MRI of the kidneys provides noninvasive evidence that strengthens the diagnosis of lithium-induced nephropathy.

Original languageEnglish (US)
Pages (from-to)828-829
Number of pages2
JournalTheScientificWorldJournal
Volume8
DOIs
StatePublished - Aug 31 2008

Fingerprint

lithium
Lithium
Kidney
cyst
Cysts
Atrophy
Fibrosis
Computerized tomography
Biopsy
Chronic Renal Insufficiency
Magnetic resonance imaging
visualization
Dilatation
Visualization
Imaging techniques
Therapeutics
therapy

Keywords

  • Cysts
  • Kidney disease
  • Lithium
  • MRI
  • Nephropathy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

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Lithium-associated kidney microcysts. / Tuazon, Jennifer A; Casalino, David; Syed, Ehteshamuddin; Batlle, Daniel.

In: TheScientificWorldJournal, Vol. 8, 31.08.2008, p. 828-829.

Research output: Contribution to journalArticle

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AU - Tuazon, Jennifer A

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AU - Syed, Ehteshamuddin

AU - Batlle, Daniel

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N2 - Long-term lithium therapy is associated with impairment in concentrating ability and, occasionally, progression to advanced chronic kidney disease from tubulointerstitial nephropathy. Biopsy findings in patients with lithium-induced chronic tubulointerstitial nephropathy include tubular atrophy and interstitial fibrosis interspersed with tubular cysts and dilatations. Recent studies have shown that cysts are seen in 33-62.5% of the patients undergoing lithium therapy. MR imaging is highly capable of defining renal morphological features and has been demonstrated to be superior to US and CT scan for the visualization of small renal cysts. The microcysts are found in both cortex and medulla, particularly in the regions with extensive atrophy and fibrosis, and can be multiple and bilateral. They tend to be sparse and do not normally exceed 1-2 mm in diameter. The renal microcysts in the image here reported are subtle, but consistent with lithium-induced chronic nephropathy. An MRI of the kidneys provides noninvasive evidence that strengthens the diagnosis of lithium-induced nephropathy.

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