LIVE-ATTENUATED COMPOSITIONS FOR BACTERIAL INFECTIONS

Anthony Schaeffer (Inventor), David Klumpp (Inventor)

Research output: Patent

Abstract

A Live-Attenuated Vaccine for Urinary Tract and Other Bacterial Infections NU 2008-004 Inventors Anthony J. Schaeffer* David J. Klumpp Benjamin Billips Abstract Urinary tract infections, either chronic or acute, are a frequent health problem in a variety of populations. Northwestern investigators have demonstrated that deletion of a certain gene from urinary-tract colonizing bacteria has resulted in a strain that promotes immune response when administered to mammalian subjects. The modified bacterium does not establish a persistent population in the bladder, but promotes cytokine secretion from urothelial cells. These bacteria represent a candidate material for a live-attenuated vaccine that could be used to protect against acute and recurrent urinary tract infections. Successful tests have been performed in a mouse model. Applications o Preventative medicine for UTIs o Alternative to repeated use of antibiotics o Particularly useful for nursing home patients or other high-risk groups Advantages o Prevents infection by stimulating patient immune system o Inexpensive, easy-to-grow bacterium o Simple to administer Publications Billips, B. Yaggie, R. Cashy, J. Schaeffer, A. Klumpp, D. (2009) A Live-Attenuated Vaccine for the Treatment of Urinary Tract Infection by Uropathogenic Escherichia Coli. The Journal of Infectious Diseases. 200(2): 263-272. IP Status A patent application has been filed. Marketing Contact Michael Moore, PhD Invention Manager (p) 847-491-4645 (e) michaelmoore@northwestern.edu
Original languageEnglish
Patent number8709444
StatePublished - Apr 19 2012

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