Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy

Anjali Sharma; Joseph G. Feldman; Elizabeth T. Golub; Julie Schmidt; Sylvia Silver; Esther Robison; Howard Minkoff

doi:10.1016/j.ajog.2007.01.005

Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy

Anjali Sharma^*, Joseph G. Feldman, Elizabeth T. Golub, Julie Schmidt, Sylvia Silver, Esther Robison, Howard Minkoff

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Objective: The objective of the study was to investigate the relationship between human immunodeficiency virus (HIV) infection and childbearing before and after the availability of highly active antiretroviral therapy (HAART). Methods: Enrollment in the Women's Interagency HIV study took place in 1994-1995 (pre-HAART era) and again in 2001-2002 (HAART era). Live birth rates prior to enrollment were compared between treatment era cohorts for HIV-infected and HIV-uninfected women aged 15-44 years using Poisson regression. For HIV-infected women, we included live births between HIV diagnosis date and study entry; the HAART era cohort included only women diagnosed with HIV in 1996 and afterward. Results: Among HIV-infected women, the HAART era live birth rate was 150% higher than in the pre-HAART era (P = .001) vs a 5% increase among HIV-uninfected women. The rate of increase in live birth rate was higher for women ≥35 years old (vs younger than 25 years, P = .02), and with more than a high school education (vs. less than high school, P = .05). Conclusion: The availability of effective therapeutic interventions has had a profound impact on child-bearing among HIV-infected women.

Original language	English (US)
Pages (from-to)	541.e1-541.e6
Journal	American journal of obstetrics and gynecology
Volume	196
Issue number	6
DOIs	https://doi.org/10.1016/j.ajog.2007.01.005
State	Published - Jun 2007

Funding

Data in this manuscript were collected by the WIHS Collaborative Study Group with centers (principal Investigators) at New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington, DC, Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); Data Coordinating Center (Stephen Gange). The WIHS is funded by the National Institute of Allergy and Infectious Diseases with supplemental funding from the National Cancer Institute, the National Institute on Drug Abuse (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590). Funding is also provided by the National Institute of Child Health and Human Development (UO1-HD-32632) and the National Center for Research Resources (MO1-RR-00071, MO1-RR-00079, and MO1-RR-00083).

Keywords

birth rate
highly active antiretroviral therapy
human immunodeficiency virus
reproductive decision making
women

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajog.2007.01.005

Cite this

@article{197900cfc3f8433da30b0f7967773eb5,

title = "Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy",

abstract = "Objective: The objective of the study was to investigate the relationship between human immunodeficiency virus (HIV) infection and childbearing before and after the availability of highly active antiretroviral therapy (HAART). Methods: Enrollment in the Women's Interagency HIV study took place in 1994-1995 (pre-HAART era) and again in 2001-2002 (HAART era). Live birth rates prior to enrollment were compared between treatment era cohorts for HIV-infected and HIV-uninfected women aged 15-44 years using Poisson regression. For HIV-infected women, we included live births between HIV diagnosis date and study entry; the HAART era cohort included only women diagnosed with HIV in 1996 and afterward. Results: Among HIV-infected women, the HAART era live birth rate was 150% higher than in the pre-HAART era (P = .001) vs a 5% increase among HIV-uninfected women. The rate of increase in live birth rate was higher for women ≥35 years old (vs younger than 25 years, P = .02), and with more than a high school education (vs. less than high school, P = .05). Conclusion: The availability of effective therapeutic interventions has had a profound impact on child-bearing among HIV-infected women.",

keywords = "birth rate, highly active antiretroviral therapy, human immunodeficiency virus, reproductive decision making, women",

author = "Anjali Sharma and Feldman, {Joseph G.} and Golub, {Elizabeth T.} and Julie Schmidt and Sylvia Silver and Esther Robison and Howard Minkoff",

note = "Funding Information: Data in this manuscript were collected by the WIHS Collaborative Study Group with centers (principal Investigators) at New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington, DC, Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); Data Coordinating Center (Stephen Gange). The WIHS is funded by the National Institute of Allergy and Infectious Diseases with supplemental funding from the National Cancer Institute, the National Institute on Drug Abuse (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590). Funding is also provided by the National Institute of Child Health and Human Development (UO1-HD-32632) and the National Center for Research Resources (MO1-RR-00071, MO1-RR-00079, and MO1-RR-00083). ",

year = "2007",

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doi = "10.1016/j.ajog.2007.01.005",

language = "English (US)",

volume = "196",

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journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

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Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy. / Sharma, Anjali; Feldman, Joseph G.; Golub, Elizabeth T. et al.
In: American journal of obstetrics and gynecology, Vol. 196, No. 6, 06.2007, p. 541.e1-541.e6.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy

AU - Sharma, Anjali

AU - Feldman, Joseph G.

AU - Golub, Elizabeth T.

AU - Schmidt, Julie

AU - Silver, Sylvia

AU - Robison, Esther

AU - Minkoff, Howard

N1 - Funding Information: Data in this manuscript were collected by the WIHS Collaborative Study Group with centers (principal Investigators) at New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington, DC, Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); Data Coordinating Center (Stephen Gange). The WIHS is funded by the National Institute of Allergy and Infectious Diseases with supplemental funding from the National Cancer Institute, the National Institute on Drug Abuse (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590). Funding is also provided by the National Institute of Child Health and Human Development (UO1-HD-32632) and the National Center for Research Resources (MO1-RR-00071, MO1-RR-00079, and MO1-RR-00083).

PY - 2007/6

Y1 - 2007/6

N2 - Objective: The objective of the study was to investigate the relationship between human immunodeficiency virus (HIV) infection and childbearing before and after the availability of highly active antiretroviral therapy (HAART). Methods: Enrollment in the Women's Interagency HIV study took place in 1994-1995 (pre-HAART era) and again in 2001-2002 (HAART era). Live birth rates prior to enrollment were compared between treatment era cohorts for HIV-infected and HIV-uninfected women aged 15-44 years using Poisson regression. For HIV-infected women, we included live births between HIV diagnosis date and study entry; the HAART era cohort included only women diagnosed with HIV in 1996 and afterward. Results: Among HIV-infected women, the HAART era live birth rate was 150% higher than in the pre-HAART era (P = .001) vs a 5% increase among HIV-uninfected women. The rate of increase in live birth rate was higher for women ≥35 years old (vs younger than 25 years, P = .02), and with more than a high school education (vs. less than high school, P = .05). Conclusion: The availability of effective therapeutic interventions has had a profound impact on child-bearing among HIV-infected women.

AB - Objective: The objective of the study was to investigate the relationship between human immunodeficiency virus (HIV) infection and childbearing before and after the availability of highly active antiretroviral therapy (HAART). Methods: Enrollment in the Women's Interagency HIV study took place in 1994-1995 (pre-HAART era) and again in 2001-2002 (HAART era). Live birth rates prior to enrollment were compared between treatment era cohorts for HIV-infected and HIV-uninfected women aged 15-44 years using Poisson regression. For HIV-infected women, we included live births between HIV diagnosis date and study entry; the HAART era cohort included only women diagnosed with HIV in 1996 and afterward. Results: Among HIV-infected women, the HAART era live birth rate was 150% higher than in the pre-HAART era (P = .001) vs a 5% increase among HIV-uninfected women. The rate of increase in live birth rate was higher for women ≥35 years old (vs younger than 25 years, P = .02), and with more than a high school education (vs. less than high school, P = .05). Conclusion: The availability of effective therapeutic interventions has had a profound impact on child-bearing among HIV-infected women.

KW - birth rate

KW - highly active antiretroviral therapy

KW - human immunodeficiency virus

KW - reproductive decision making

KW - women

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JO - American journal of obstetrics and gynecology

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ER -

Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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