Liver cell labelling with MRI contrast agents

Michel Modo*, Thomas J. Meade, Ragai R. Mitry

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Cell transplantation is a promising approach to improve the life of patients with liver disease. At present, however, techniques to track and visualise transplanted cells in patients are fairly limited and further development of non-invasive imaging technology is needed to advance the monitoring of liver cell grafts. Magnetic resonance imaging (MRI) is a non-invasive imaging technology that already allows the visualisation of particular cell fractions in the liver by using MR contrast agents. The use of contrast agents to pre-label liver cells prior to transplantation will potentially provide a method to identify, track and study the integration of engrafted cells non-invasively by MRI. Before this technique can find its clinical application, in vitro and pre-clinical in vivo studies need to be conducted to determine the safety and specificity of this approach.

Original languageEnglish (US)
Title of host publicationHepatocyte Transplantation
Subtitle of host publicationMethods and Protocols
PublisherHumana Press
Pages207-219
Number of pages13
ISBN (Print)9781588298836
DOIs
StatePublished - 2009

Publication series

NameMethods in Molecular Biology
Volume481
ISSN (Print)1064-3745

Keywords

  • Cell Transplant, liver, MRI, contrast agent, cellular MRI, gadolinium, iron oxide

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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