Liver cell-mediated alleviation of acute ischemic myocardial injury

Shu Qian Liu*, Yu H. Wu

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cardiomyocyte injury occurs in myocardial ischemia, resulting in impairment of cardiac function. As the endogenous protective function of adult cardiomyocytes is limited, nonmyocytic cells may be activated to protect myocardium from ischemic injury. In this investigation, we demonstrated in a mouse model of myocardial ischemia that the liver was able to respond to myocardial ischemia to upregulate a number of genes encoding secreted proteins, mobilize its cells, and release cell contents into the circulatory system. These naturally occurring mechanisms suggested a possible cardioprotective role for myocardial ischemia-conditioned liver cells and inspired us to develop cardioprotective therapies based on these mechanisms. We demonstrated that administration of liver cell extract derived from myocardial ischemic mice, but not sham control mice, resulted in a significant reduction in acute myocardial infarction as well as the density of TUNEL+ cells in ischemic myocardium compared to administration of PBS at 2, 6, 12, and 24 hrs. These observations suggest that liver cells may respond to myocardial ischemia to express cardioprotective factors, which may be identified and used for alleviating myocardial infarction.

Original languageEnglish (US)
Pages (from-to)711-724
Number of pages14
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number2
StatePublished - Jan 1 2010

Fingerprint

Liver
Myocardial Ischemia
Wounds and Injuries
Cardiac Myocytes
Myocardium
Gene encoding
Myocardial Infarction
Liver Extracts
In Situ Nick-End Labeling
Cardiovascular System
Cell Extracts
Up-Regulation
Cell Count
Proteins
Genes
Therapeutics

Keywords

  • Cardioprotection
  • Hepatocytes
  • Myocardial ischemia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

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Liver cell-mediated alleviation of acute ischemic myocardial injury. / Liu, Shu Qian; Wu, Yu H.

In: Frontiers in Bioscience - Elite, Vol. 2 E, No. 2, 01.01.2010, p. 711-724.

Research output: Contribution to journalArticle

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AU - Liu, Shu Qian

AU - Wu, Yu H.

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AB - Cardiomyocyte injury occurs in myocardial ischemia, resulting in impairment of cardiac function. As the endogenous protective function of adult cardiomyocytes is limited, nonmyocytic cells may be activated to protect myocardium from ischemic injury. In this investigation, we demonstrated in a mouse model of myocardial ischemia that the liver was able to respond to myocardial ischemia to upregulate a number of genes encoding secreted proteins, mobilize its cells, and release cell contents into the circulatory system. These naturally occurring mechanisms suggested a possible cardioprotective role for myocardial ischemia-conditioned liver cells and inspired us to develop cardioprotective therapies based on these mechanisms. We demonstrated that administration of liver cell extract derived from myocardial ischemic mice, but not sham control mice, resulted in a significant reduction in acute myocardial infarction as well as the density of TUNEL+ cells in ischemic myocardium compared to administration of PBS at 2, 6, 12, and 24 hrs. These observations suggest that liver cells may respond to myocardial ischemia to express cardioprotective factors, which may be identified and used for alleviating myocardial infarction.

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