Liver transplantation, including the concept of reduced-size liver transplants in children

C. E. Broelsch, J. C. Emond, J. R. Thistlethwaite, P. F. Whitington, A. R. Zucker, A. L. Baker, P. F. Aran, D. A. Rouch, J. L. Lichtor

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

Since the establishment of a clinical program in liver transplantation in 1984, 162 liver transplants have been performed in 131 patients (78 adults, 53 children). The patient mortality rate while waiting for a suitable organ has been 8% for adults and only 4% for children (25-46% reported in the literature). The low pediatric mortality is a result of the use of reduced-size liver transplants. A total of 14 procedures have been performed in recipients whose clinical condition was deteriorating and for whom no full-size graft could be located. Of 14 children, 13 were less than 3 years of age. Patient survival is 50%, comparable to survival of high-risk recipients of full-size livers. Using reduced-size liver grafting in a transplant program can lower mortality for children awaiting a transplant by overcoming size disparity. Reduced-size liver grafting will allow more effective use of donor resources and provide a potential avenue of research for organ splitting and living related donation.

Original languageEnglish (US)
Pages (from-to)410-420
Number of pages11
JournalAnnals of surgery
Volume208
Issue number4
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Surgery

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