LncRNA, a new component of expanding RNA-protein regulatory network important for animal sperm development

Chenwang Zhang, Liuze Gao, Eugene Yujun Xu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Spermatogenesis is one of the fundamental processes of sexual reproduction, present in almost all metazoan animals. Like many other reproductive traits, developmental features and traits of spermatogenesis are under strong selective pressure to change, both at morphological and underlying molecular levels. Yet evidence suggests that some fundamental features of spermatogenesis may be ancient and conserved among metazoan species. Identifying the underlying conserved molecular mechanisms could reveal core components of metazoan spermatogenic machinery and provide novel insight into causes of human infertility. Conserved RNA-binding proteins and their interacting RNA network emerge to be a common theme important for animal sperm development. We review research on the recent addition to the RNA family – Long non-coding RNA (lncRNA) and its roles in spermatogenesis in the context of the expanding RNA-protein network.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume59
DOIs
StatePublished - Nov 1 2016

Keywords

  • Conservation
  • Evolution of reproduction
  • LncRNA
  • Noncoding RNA
  • RNA binding proteins
  • Spermatogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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