Local administration of therapies and drug delivery strategies for the treatment of gliomas

Víctor A. Arrieta; Daniel Zhang; Adam M. Sonabend

doi:10.1007/978-3-030-54879-7_19

Local administration of therapies and drug delivery strategies for the treatment of gliomas

Víctor A. Arrieta, Daniel Zhang, Adam M. Sonabend^*

^*Corresponding author for this work

Neurological Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Currently, glioblastomas remain incurable and are associated with a poor prognosis. Although the understanding of the biology of gliomas has been refined, little progress has been made in the therapeutic management of these tumors. Part of this failure is because the blood-brain barrier has prevented the inlet of new and standard therapeutics into the tumor territory and its vicinity. Therefore, effective strategies are needed to achieve good drug concentrations within tumors. This chapter addresses promising drug-delivery technologies such as convection-enhanced delivery and ultrasound, that have experienced an increasing use in preclinical and clinical research and have an enormous potential for implementation for the treatment of gliomas.

Original language	English (US)
Title of host publication	Principles of Neuro-Oncology: Brain & Skull Base
Publisher	Springer International Publishing
Pages	385-394
Number of pages	10
ISBN (Electronic)	9783030548797
ISBN (Print)	9783030548780
DOIs	https://doi.org/10.1007/978-3-030-54879-7_19
State	Published - Dec 23 2020

Keywords

Blood-brain barrier
Convection-enhanced delivery
Glioblastoma
Gliomas
Ultrasound

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-030-54879-7_19

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abstract = "Currently, glioblastomas remain incurable and are associated with a poor prognosis. Although the understanding of the biology of gliomas has been refined, little progress has been made in the therapeutic management of these tumors. Part of this failure is because the blood-brain barrier has prevented the inlet of new and standard therapeutics into the tumor territory and its vicinity. Therefore, effective strategies are needed to achieve good drug concentrations within tumors. This chapter addresses promising drug-delivery technologies such as convection-enhanced delivery and ultrasound, that have experienced an increasing use in preclinical and clinical research and have an enormous potential for implementation for the treatment of gliomas.",

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AB - Currently, glioblastomas remain incurable and are associated with a poor prognosis. Although the understanding of the biology of gliomas has been refined, little progress has been made in the therapeutic management of these tumors. Part of this failure is because the blood-brain barrier has prevented the inlet of new and standard therapeutics into the tumor territory and its vicinity. Therefore, effective strategies are needed to achieve good drug concentrations within tumors. This chapter addresses promising drug-delivery technologies such as convection-enhanced delivery and ultrasound, that have experienced an increasing use in preclinical and clinical research and have an enormous potential for implementation for the treatment of gliomas.

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Local administration of therapies and drug delivery strategies for the treatment of gliomas

Abstract

Keywords

ASJC Scopus subject areas

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