Local anesthesia and pain perception during amniocentesis: A randomized double blind placebo-controlled trial

Andrew Elimian*, Jean R. Goodman, Eric Knudtson, Andrew Wagner, Patrick Wilson, Marvin Williams

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To determine the effect of local anesthesia on the maternal pain perception from amniocentesis. Methods: We conducted a randomized double blind placebo controlled trial comparing use of local anesthesia (1% lidocaine) with placebo with regards to maternal perception of pain among women undergoing genetic amniocentesis. The primary outcome was the intensity of perceived maternal pain as measured by the Visual Analogue Scale (VAS) as well a 101 point Numerical Rating Scale. Results: Seventy six women participated in the trial. 36 (47.4%) women were randomized to lidocaine, whereas 40 (52.6%) were randomized to placebo. There were no statistically significant differences between the groups in terms of baseline sociodemographic and clinical characteristics. However, pain perception as characterized by the median 9.5 (2.1-21.0) VSA scores was significantly lower among women in the lidocaine group compared with among women in the placebo group [18.4 (12.9-31.3), P=0.005]. Similarly the mean VSA scores was significantly lower in the lidocaine group (P=0.02). A trend toward lower scores was also observed when maternal pain perception was measured by the Numerical Rating Scale. Conclusion: Local anesthetic lidocaine significantly lowers maternal perceived pain during genetic amniocentesis.

Original languageEnglish (US)
Pages (from-to)1158-1161
Number of pages4
JournalPrenatal Diagnosis
Volume33
Issue number12
DOIs
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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