Local delivery of diflunisal protects host bone tissue from s. Aureus biofilm-induced bone destruction

T. J. Spoonmore, A. S. Hendrix, J. E. Cassat, S. A. Guelcher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Implementation of tissue engineered bone scaffolds can often lead to infectious complications due to the development of biofilms on the bone surface1. Biofilms demonstrate advanced cell-cell communication and can lead to pathogen-induced bone destruction through virulent factors produced by the accessory gene regulator (agr) locus2. Diflunisal (Dif) is an FDA-approved nonsteroidal anti-inflammatory compound known to inhibit S. aureus virulence factor production through the agr locus3. Dif, however, also interrupts agr-mediated cell-cell communication, and the capabilities of clinically relevant antibiotics such as vancomycin (Vanc) to eradicate cells in to presence of Dif has not been studied. In this work, we investigated (1) the capabilities of locally delivered Dif from PUR foams to preserve host tissue during biofilm development, and (2) the effects of Dif treatment on Vanc capabilities to eradicate an established biofilm infection.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages781
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Local delivery of diflunisal protects host bone tissue from s. Aureus biofilm-induced bone destruction'. Together they form a unique fingerprint.

Cite this