TY - GEN
T1 - Local delivery of diflunisal protects host bone tissue from s. Aureus biofilm-induced bone destruction
AU - Spoonmore, T. J.
AU - Hendrix, A. S.
AU - Cassat, J. E.
AU - Guelcher, S. A.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Introduction: Implementation of tissue engineered bone scaffolds can often lead to infectious complications due to the development of biofilms on the bone surface1. Biofilms demonstrate advanced cell-cell communication and can lead to pathogen-induced bone destruction through virulent factors produced by the accessory gene regulator (agr) locus2. Diflunisal (Dif) is an FDA-approved nonsteroidal anti-inflammatory compound known to inhibit S. aureus virulence factor production through the agr locus3. Dif, however, also interrupts agr-mediated cell-cell communication, and the capabilities of clinically relevant antibiotics such as vancomycin (Vanc) to eradicate cells in to presence of Dif has not been studied. In this work, we investigated (1) the capabilities of locally delivered Dif from PUR foams to preserve host tissue during biofilm development, and (2) the effects of Dif treatment on Vanc capabilities to eradicate an established biofilm infection.
AB - Introduction: Implementation of tissue engineered bone scaffolds can often lead to infectious complications due to the development of biofilms on the bone surface1. Biofilms demonstrate advanced cell-cell communication and can lead to pathogen-induced bone destruction through virulent factors produced by the accessory gene regulator (agr) locus2. Diflunisal (Dif) is an FDA-approved nonsteroidal anti-inflammatory compound known to inhibit S. aureus virulence factor production through the agr locus3. Dif, however, also interrupts agr-mediated cell-cell communication, and the capabilities of clinically relevant antibiotics such as vancomycin (Vanc) to eradicate cells in to presence of Dif has not been studied. In this work, we investigated (1) the capabilities of locally delivered Dif from PUR foams to preserve host tissue during biofilm development, and (2) the effects of Dif treatment on Vanc capabilities to eradicate an established biofilm infection.
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M3 - Conference contribution
AN - SCOPUS:85065430149
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 781
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -