Abstract
The spiking activity of populations of cortical neurons is well described by the dynamics of a small number of population-wide covariance patterns, whose activation we refer to as ‘latent dynamics’. These latent dynamics are largely driven by the same correlated synaptic currents across the circuit that determine the generation of local field potentials (LFPs). Yet, the relationship between latent dynamics and LFPs remains largely unexplored. Here, we characterised this relationship for three different regions of primate sensorimotor cortex during reaching. The correlation between latent dynamics and LFPs was frequency-dependent and varied across regions. However, for any given region, this relationship remained stable throughout the behaviour: in each of primary motor and premotor cortices, the LFP-latent dynamics correlation profile was remarkably similar between movement planning and execution. These robust associations between LFPs and neural population latent dynamics help bridge the wealth of studies reporting neural correlates of behaviour using either type of recordings.
| Original language | English (US) |
|---|---|
| Article number | e73155 |
| Journal | eLife |
| Volume | 11 |
| DOIs | |
| State | Published - 2022 |
Funding
This work was supported in part by: grant F31-NS092356 from the National Institute of Neurological Disorder and Stroke, and grant T32-HD07418 from the National Institute of Child Health and Human Development (MGP); graduate research fellowship DGE-1324585 from the National Science Founda-tion, and grant T32-NS086749 from the National Institute of Neurological Disorder and Stroke (RHC); grants NS053603, NS074044, and NS095251 from the National Institute of Neurological Disorder and Stroke (LEM); and grant 2017-T2/TIC-5263 from the Community of Madrid, grant PGC2018-095846-A-I00 from the Spanish Ministry of Science and Innovation, grant EP/T020970/1 from the UKRI Engineering and Physical Sciences Research Council, and grant ERC-2020-StG-949660 from the European Research Council (JAG). Funder Grant reference number Author National Institute of Neurological Disorders and Stroke National Science Foundation National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke F31-NS092356 DGE-1324585 T32-NS086749 NS053603 NS074044 NS095251 Matthew G Perich Raeed H Chowdhury Raeed H Chowdhury Lee E Miller Lee E Miller Lee E Miller Comunidad de Madrid 2017-T2/TIC-5263 Juan Álvaro Gallego Ministerio de Ciencia e Innovación Engineering and Physical Sciences Research Council European Research Council PGC2018-095846-A-I00 EP/T020970/1 ERC-2020-StG-949660 Juan Álvaro Gallego Juan Álvaro Gallego Juan Álvaro Gallego The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. This work was supported in part by: grant F31-NS092356 from the National Institute of Neurological Disorder and Stroke, and grant T32-HD07418 from the National Institute of Child Health and Human Development (MGP); graduate research fellowship DGE-1324585 from the National Science Foundation, and grant T32-NS086749 from the National Institute of Neurological Disorder and Stroke (RHC); grants NS053603, NS074044, and NS095251 from the National Institute of Neurological Disorder and Stroke (LEM); and grant 2017-T2/TIC-5263 from the Community of Madrid, grant PGC2018-095846-A-I00 from the Spanish Ministry of Science and Innovation, grant EP/T020970/1 from the UKRI Engineering and Physical Sciences Research Council, and grant ERC-2020-StG-949660 from the European Research Council (JAG).
ASJC Scopus subject areas
- General Immunology and Microbiology
- General Biochemistry, Genetics and Molecular Biology
- General Neuroscience