Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12

T. A. Donlon*, A. M. Krensky, M. R. Wallace, F. S. Collins, M. Lovett, C. Clayberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

We report here the localization of the gene for a human T-cell-specific molecule, designated RANTES, to human chromosome region 17q11.2-q12 by in situ hybridization and analysis of somatic cell hybrids using a cDNA probe to the gene. We have recently shown that this gene, which encodes a small, secreted, putative lymphokine, is a member of a larger gene family some of whose members reside on chromosome 4 but most of whose members have not to date been mapped. A secondary hybridization peak was noted on the region of human chromosome 5q31-q34, which may represent the location of other members of the gene family. Interestingly, this latter region overlaps with the location of an extended linked cluster of growth factor and receptor genes, some of which may be coregulated with members of the RANTES gene family.

Original languageEnglish (US)
Pages (from-to)548-553
Number of pages6
JournalGenomics
Volume6
Issue number3
DOIs
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Genetics

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