Localization of expression of human beta defensin-1 in the pancreas and kidney

Denni Schnapp, Colm J. Reid, Ann Harris*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Defensins are antimicrobial peptides which play a key role in innate immunity. High levels of human beta defensin-1 (hBD-1) have previously been detected in the kidney and pancreas, but the cell-specific location of hBD-1 mRNA has not been determined. The expression of hBD-1 mRNA has been examined in fetal and adult pancreas and kidney by mRNA in situ hybridization. In fetal pancreas, hBD-1 expression was detected in the developing acini and in adult pancreas in the acini, but not in the pancreatic ducts. In both fetal and adult kidney, hBD-1 expression was detected in the collecting ducts and in the loops of Henle in adult kidney. Expression of hBD-1 mRNA in the pancreas and kidney from early development and in the acini of the adult pancreas, rather than in the pancreatic ducts, may indicate that in these tissues, hBD-1 fulfills physiological functions in addition to host defence.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Pathology
Volume186
Issue number1
DOIs
StatePublished - Sep 1998

Keywords

  • In situ hybridization
  • Kidney
  • Pancreas
  • hBD-1 mRNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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