Localization of placental lactogen-I in trophoblast giant cells of the mouse placenta

T. N. Faria, L. Ogren, F. Talamantes, D. I H Linzer, M. J. Soares*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

The purpose of this investigation was to identify the cellular origin of placental lactogen-I (PL-I) expression in the mouse placenta and to cytologically define the transition from PL-I to PL-II expression during gestation. PL-I mRNA expression was assessed by in situ hybridization, and expression of PL-I and PL-II protein was determined by immunocytochemical analysis. PL-I mRNA and protein were localized to trophoblast giant cells. Trophoblast giant cells ceased producing PL-I at midgestation and began expressing PL-II. PL-I immunoreactivity was present in trophoblast giant cells on Days 9 and 10 of gestation but was not detectable in trophoblast giant cells on Day 11 of gestation. Immunoreactive PL-II-producing giant cells were detected first on Day 10 of gestation, continuing on Day 11 of gestation. Expression of PL-I and PL-II signals a significant functional transition in trophoblast giant cells of the developing mouse placenta.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalBiology of reproduction
Volume44
Issue number2
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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