TY - JOUR
T1 - Localization of ro (ss‐a) antigen in the cardiac conduction system
AU - Deng, Jau‐Shyong ‐S
AU - Bair, Louis W.
AU - Shen‐Schwarz, Susan
AU - Ramsey‐Goldman, Rosalind
AU - Medsger, Thomas
PY - 1987/11
Y1 - 1987/11
N2 - The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.
AB - The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.
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U2 - 10.1002/art.1780301105
DO - 10.1002/art.1780301105
M3 - Article
C2 - 3318846
AN - SCOPUS:0023491372
SN - 0004-3591
VL - 30
SP - 1232
EP - 1238
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 11
ER -