Localization of ro (ss‐a) antigen in the cardiac conduction system

Jau‐Shyong ‐S Deng*, Louis W. Bair, Susan Shen‐Schwarz, Rosalind Ramsey‐Goldman, Thomas Medsger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.

Original languageEnglish (US)
Pages (from-to)1232-1238
Number of pages7
JournalArthritis & Rheumatism
Volume30
Issue number11
DOIs
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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