Localization of ro (ss‐a) antigen in the cardiac conduction system

Jau‐Shyong ‐S Deng; Louis W. Bair; Susan Shen‐Schwarz; Rosalind Ramsey‐Goldman; Thomas Medsger

doi:10.1002/art.1780301105

Localization of ro (ss‐a) antigen in the cardiac conduction system

Jau‐Shyong ‐S Deng^*, Louis W. Bair, Susan Shen‐Schwarz, Rosalind Ramsey‐Goldman, Thomas Medsger

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.

Original language	English (US)
Pages (from-to)	1232-1238
Number of pages	7
Journal	Arthritis & Rheumatism
Volume	30
Issue number	11
DOIs	https://doi.org/10.1002/art.1780301105
State	Published - Nov 1987

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.",

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AU - Deng, Jau‐Shyong ‐S

AU - Bair, Louis W.

AU - Shen‐Schwarz, Susan

AU - Ramsey‐Goldman, Rosalind

AU - Medsger, Thomas

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AB - The presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.

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