Localized surface plasmon and molecular resonance: Fundamental study and application

Jing Zhao*, Xiaoyu Zhang, Amanda J. Haes, Shengli Zou, George C. Schatz, Richard P. Van Duyne

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


Localized surface plasmon resonance (LSPR) is one of the signature optical properties of noble metal nanoparticles. Since the LSPR wavelength λ max is extremely sensitive to the local environment, it allows us to develop nanoparticle-based LSPR chemical and biological sensors. In this work, we tuned the LSPR peaks of Ag nanotriangles and explored the wavelength-dependent LSPR shift upon the adsorption of some resonant molecules. The induced LSPR peak shifts (λ max) vary with wavelength and the line shape of the LSPR shift is closely related to the absorption features of the resonant molecules. When the LSPR of the nanoparticles directly overlaps with the molecular resonance, a very small LSPR shift was observed. An amplified LSPR shift is found when LSPR of the nanoparticles is at a slightly longer wavelength than the molecular resonance of the adsorbates. Furthermore, we apply the "amplified" LSPR shift to detect the substrate binding of camphor to the heme-containing cytochrome P450cam protiens (CYP101). CYP101 absorb light in the visible region. When a small substrate molecule binds to CYP101, the spin state of the molecule is converted to its low spin state. By fabricating nanoparticles with the LSPR close to the molecular resonance of CYP101 proteins, the LSPR response as large as -60 nm caused by the binding of small substrate has been demonstrated.

Original languageEnglish (US)
Title of host publicationPlasmonics
Subtitle of host publicationMetallic Nanostructures and their Optical Properties IV
StatePublished - 2006
EventPlasmonics: Metallic Nanostructures and their Optical Properties IV - San Diego, CA, United States
Duration: Aug 13 2006Aug 16 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherPlasmonics: Metallic Nanostructures and their Optical Properties IV
Country/TerritoryUnited States
CitySan Diego, CA


  • Cytochrome P450
  • Discrete dipole approximation
  • Kramers-Kronig transformation
  • Localized surface plasmon resonance
  • Molecular resonance
  • Nanosphere lithography
  • Substrate binding

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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