Locked nucleic acid-nanoparticle conjugates

Dwight S. Seferos, David A. Giljohann, Nathaniel L. Rosi, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

(Figure Presented) Designer nanoparticle conjugates. Locked nucleic acid (LNA) oligonucleotides can be used to functionalize nanoparticles to yield a novel conjugate that is highly stable and has a remarkably high affinity for complementary nucleic acids. When tested in a cell line model, these conjugates were found to be effective at controlling survivin gene expression.

Original languageEnglish (US)
Pages (from-to)1230-1232
Number of pages3
JournalChemBioChem
Volume8
Issue number11
DOIs
StatePublished - Jul 23 2007

Keywords

  • Gene expression
  • Gold
  • Nanostructures
  • Nanotechnology
  • Nucleic acids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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