Locus coeruleus and intracranial self-stimulation: A cautionary note

David G. Amaral*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


In an effort to confirm the presence of intracranial self-stimulation (ICSS) within the locus coeruleus, an ICSS testing procedure typically employed in our laboratory was used. Eighty male albino rats were implanted with bipolar electrodes made with either 78.7-μm or 254-μm nichrome wire. ICSS was not observed with electrodes in or adjacent to the locus coeruleus. Examination of the histological material revealed that some of the small-diameter electrodes were embedded within the locus coeruleus and yet no ICSS could be demonstrated in such cases. These results contrast with ICSS that we have observed previously in frontal cortex, both medial and sulcal, septohippocampal area, lateral hypothalamus, ventral midbrain tegmentum, and dorsal tegmentum in the region of the decussation of the superior cerebellar peduncle.

Original languageEnglish (US)
Pages (from-to)331-338
Number of pages8
JournalBehavioral Biology
Issue number3
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)


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