Locus determining the human sperm‐specific lactate dehydrogenase, LDHC, is syntenic with LDHC

Yvonne H. Edwards, Sue Povey, Kay M. Levan, Catherine E. Driscoll, Jose Luis Millan, Erwin Goldberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

From the data presented in this report, the human LDHC gene locus is assigned to chromosome 11. Three genes determine lactate dehydrogenase (LDH) in man. LDHA and LDHB are expressed in most somatic tissues, while expression of LDHC is confined to the germinal epithelium of the testes. A human LDHC cDNA clone was used as a probe to analyze genomic DNA from rodent/human somatic cell hybrids. The pattern of bands with LDHC hybridization is easily distinguished from the pattern detected by LDHA hybridization, and the LDHC probe is specific for testis mRNA. The structural gene LDHA has been previously assigned to human chromosome 11, while LDHB maps to chromosome 12. Studies of pigeon LDH have shown tight linkage between LDHB and LDHC leading to the expectation that these genes would be syntenic in man. However, the data presented in this paper show conclusively that LDHC is syntenic with LDHA on human chromosome 11. The terminology for LDH genes LDHA, LDHB, and LDHC is equivalent to Ldhl, Ldh2, and Ldh3, respectively.

Original languageEnglish (US)
Pages (from-to)219-232
Number of pages14
JournalDevelopmental Genetics
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1987

Keywords

  • evolution
  • gene mapping
  • lactate dehydrogenase
  • multigene enzyme family
  • somatic cell hybrids
  • spermatogenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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