Long bone fracture characteristics in children with medical conditions linked to bone health

Kristine Fortin*, Gina Bertocci, Jennifer Lynn Nicholas, Douglas John Lorenz, Mary Clyde Pierce

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Knowledge of fracture characteristics among children with medical conditions affecting bone could help to distinguish medical causes from child abuse. Objective: Characterize long bone fracture morphology among children diagnosed with medical conditions linked to bone health. Participants and setting: Patients <18 years at a single pediatric hospital diagnosed with a medical condition linked to bone health and ≥1 long bone fracture were studied. Methods: This retrospective medical record review categorized underlying medical diagnoses as: metabolic bone disease, genetic disorder of connective tissue, neurologic disorder and other chronic disease. A pediatric radiologist reviewed plain films to determine fracture type and location. Descriptive statistics, as well as logistic regression were used to compare fracture types by clinical characteristics. Results: Ninety-four patients were included and their diagnoses were genetic connective disorder (19; 20.2 %), metabolic bone disease (16; 17.0 %), neurologic disorder (27; 28.7 %), and other (32; 34.0 %). A total of 216 long bone fractures were sustained; 52.1 % of children had >1 long bone fracture. Of the 216 fractures, 55 (25.5 %) were in children < 1 year, 118 (54.6 %) were associated with known trauma, and 122 (56.5 %) were in non-ambulatory patients. Lower extremity fractures occurred with greatest frequency and most fractures occurred at the mid-diaphysis. Transverse was the most common fracture type in all diagnostic categories. Children with metabolic disorders had highest odds of transverse fracture (COR 3.55, CI 1.45–8.67; neurologic disorders as reference group). Conclusions: Diseases affecting bone health can influence fracture morphology. Transverse fractures were most common in bones impacted by disease.

Original languageEnglish (US)
Article number104396
JournalChild Abuse and Neglect
StatePublished - May 2020


  • Bone diseases
  • Children
  • Fractures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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