Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

George C. Wagner, George A. Ricaurte, Lewis S. Seiden*, Charles R. Schuster, Richard J. Miller, John Westley

*Corresponding author for this work

Research output: Contribution to journalArticle

457 Citations (Scopus)

Abstract

Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalBrain research
Volume181
Issue number1
DOIs
StatePublished - Jan 6 1980

Fingerprint

Corpus Striatum
Methamphetamine
Dopamine
Dopaminergic Neurons
Dopamine Receptors
Norepinephrine
Brain
Pharmaceutical Preparations

Keywords

  • catecholamines
  • dopamine
  • methamphetamine
  • toxicity
  • uptake kinetics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Wagner, George C. ; Ricaurte, George A. ; Seiden, Lewis S. ; Schuster, Charles R. ; Miller, Richard J. ; Westley, John. / Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. In: Brain research. 1980 ; Vol. 181, No. 1. pp. 151-160.
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Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. / Wagner, George C.; Ricaurte, George A.; Seiden, Lewis S.; Schuster, Charles R.; Miller, Richard J.; Westley, John.

In: Brain research, Vol. 181, No. 1, 06.01.1980, p. 151-160.

Research output: Contribution to journalArticle

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