Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

George C. Wagner; George A. Ricaurte; Lewis S. Seiden; Charles R. Schuster; Richard J. Miller; John Westley

doi:10.1016/0006-8993(80)91265-2

Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

George C. Wagner, George A. Ricaurte, Lewis S. Seiden^*, Charles R. Schuster, Richard J. Miller, John Westley

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

486 Scopus citations

Abstract

Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

Original language	English (US)
Pages (from-to)	151-160
Number of pages	10
Journal	Brain research
Volume	181
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)91265-2
State	Published - Jan 6 1980

Funding

This study was supported in part by USPHS NIDA Grants DA 00250 and DA

Keywords

catecholamines
dopamine
methamphetamine
toxicity
uptake kinetics

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(80)91265-2

Cite this

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abstract = "Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.",

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AU - Wagner, George C.

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AU - Seiden, Lewis S.

AU - Schuster, Charles R.

AU - Miller, Richard J.

AU - Westley, John

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AB - Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

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KW - uptake kinetics

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Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

Abstract

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Keywords

ASJC Scopus subject areas

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