Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

George C. Wagner, George A. Ricaurte, Lewis S. Seiden*, Charles R. Schuster, Richard J. Miller, John Westley

*Corresponding author for this work

Research output: Contribution to journalArticle

461 Scopus citations


Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalBrain research
Issue number1
StatePublished - Jan 6 1980



  • catecholamines
  • dopamine
  • methamphetamine
  • toxicity
  • uptake kinetics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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