Long-lived mitochondrial proteins and why they exist

Ewa Bomba-Warczak, Jeffrey N. Savas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Intracellular long-lived proteins (LLPs) provide structural support for several highly stable protein complexes and assemblies that play essential roles in ensuring cellular homeostasis and function. Recently, mitochondrial long-lived proteins (mt-LLPs) were discovered within inner mitochondria membranes (IMMs) and cristae invagination in tissues with old postmitotic cells. This observation is at odds with the fact that mitochondria are highly dynamic organelles that are continually remodeled through processes of fission, fusion, biogenesis, and multiple quality control pathways. In this opinion article, we propose that a subset of the mitochondrial proteome persists over long time frames and these mt-LLPs provide key structural support for the lifelong maintenance of mitochondrial structure.

Original languageEnglish (US)
Pages (from-to)646-654
Number of pages9
JournalTrends in Cell Biology
Volume32
Issue number8
DOIs
StatePublished - Aug 2022

Keywords

  • cristae ultrastructure
  • long-lived proteins
  • mitochondria
  • mitochondrial dynamics
  • protein turnover
  • stable structures

ASJC Scopus subject areas

  • Cell Biology

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