Long-range electron transfer through DNA films

Shana O. Kelley, Nicole M. Jackson, Michael G. Hill*, Jacqueline K. Barton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

415 Scopus citations


Regardless of its position within the DNA film, cross-linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine-adenine (CA) mismatch, the electrochemical response is dramatically attenuated (shown schematically). Therefore, the DNA double helix can facilitate long-range electron transfer, but only in the presence of a well-stacked pathway.

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number7
StatePublished - Apr 1 1999
Externally publishedYes


  • Biosensors
  • Cyclic voltammetry
  • DNA structures
  • Electron transfer
  • Monolayers
  • Thin films

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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