Long-standing diabetes mellitus and pancreas transplantation: An avenue to increase utilization of an ideal treatment modality

Vinayak S. Rohan*, John W. McGillicuddy, David J. Taber, Satish N. Nadig, Prabhakar K. Baliga, Charles F. Bratton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Diabetes mellitus (DM) is associated with increased post-operative complications in various surgeries. Little data exist regarding the impact of long-standing DM (>25 years) on outcomes in pancreas transplantation (PTX). The objectives of our study were to determine if long-standing pre-transplant DM (>25 years) was associated with inferior outcomes following PTX. Methods: Using a 13-year (April, 2000-May, 2012) retrospective analysis, we examined demographic and transplant factors, complications, and outcomes in patients without (Group A) and with (Group B) long-standing (>25 years) pre-PTX DM. Results: Mean follow-up was 4.2 years. Of 214 consecutive PTX performed, 137 (105 simultaneous PTX (SPK), 25 PTX after kidney (PAK), 7 PTX alone (PTA)) had pre-PTX duration of DM recorded, including 65 in Group A and 72 in Group B. There were no differences between cohorts with respect to demographics. There were no differences in post-PTX surgical/medical complications. There were no differences in outcomes between cohorts (ie, rejection, graft loss or death). Conclusions: This large-scale analysis demonstrated that PTX can be performed in patients with long-standing DM with excellent patient and graft outcomes. Long-standing DM did not lead to an increased post-PTX infections or complications. Our study suggests that duration of DM should not impact PTX candidacy.

Original languageEnglish (US)
Article numbere13695
JournalClinical Transplantation
Issue number10
StatePublished - Oct 1 2019
Externally publishedYes


  • complications
  • diabetes mellitus
  • pancreas transplantation

ASJC Scopus subject areas

  • Transplantation


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