Long-term deep brain stimulation in a patient with essential tremor: Clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Case report

John A. Boockvar*, Albert Telfeian, Gordon H. Baltuch, Brett Skolnick, Tanya Simuni, Matthew Stern, Marie L. Schmidt, John Q. Trojanowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Essential tremor can be suppressed with chronic, bilateral deep brain stimulation (DBS) of the ventralis intermedius nucleus (Vim), the cerebellar receiving area of the motor thalamus. The goal in this study was to correlate the location of the electrodes with the clinical efficacy of DBS in a patient with essential tremor. The authors report on a woman with essential tremor in whom chronic bilateral DBS directed to the ventral thalamus produced adequate tremor suppression until her death from unrelated causes 16 months after placement of the electrodes. Neuropathological postmortem studies of the brain in this patient demonstrated that both stimulators terminated in the Vim region of the thalamus, and that chronic DBS elicited minor reactive changes confined to the immediate vicinity of the electrode tracks. Although the authors could not identify neuropathological abnormalities specific to essential tremor, they believe that suppression of essential tremor by chronic DBS correlates with bilateral termination of the stimulators in the Vim region of the thalamus.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalJournal of neurosurgery
Volume93
Issue number1
DOIs
StatePublished - Jul 2000

Keywords

  • Deep brain stimulation
  • Essential tremor
  • Thalamus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Long-term deep brain stimulation in a patient with essential tremor: Clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Case report'. Together they form a unique fingerprint.

Cite this