Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's disease

Andrew Siderowf*, Jurg L. Jaggi, Sharon X. Xie, Catherine Loveland-Jones, Lewis Leng, Howard Hurtig, Amy Colcher, Matthew Stern, Kelvin L. Chou, Grace Liang, Heather Maccarone, Tatyana Simuni, Gordon Baltuch

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We evaluated the long-term effects of subthalamic nucleus (STN) stimulation on health-related quality of life (HRQL) in patients with advanced Parkinson's disease (PD). STN stimulation improves motor function and decreases medication requirements in patients with advanced PD. The impact of STN stimulation on HRQL is less well established, especially beyond 1 year after surgery. We report HRQL outcomes for 18 patients with advanced PD. Patients were evaluated with the Parkinson's Disease Questionnaire-39 (PDQ-39), the Medical Outcome Study Short Form (SF-36), and the EuroQol visual analogue scale (VAS) before surgery, 6 months postoperatively, and at a long-term follow-up visit (mean, 35.9 months; range, 18-57 months after surgery). Preoperative scores on HRQL measures were compared to results obtained at short- and long-term follow-up evaluations. The VAS and all domains of the PDQ-39 except for cognition, communication, and social support showed marked improvements at 6 months after surgery. At the long-term follow-up, there were sustained improvements in the VAS (63% improvement; P = 0.0009) and in several domains of the PDQ-39 [mobility: 20%, P = 0.01; activities of daily living (ADL): 29%, P = 0.005; emotional well-being: 26%, P = 0.02; stigma: 43%, P = 0.003; and bodily discomfort: 35%, P = 0.007]. At the long-term evaluation, only the vitality domain of the SF-36 was significantly improved from baseline (16%; P = 0.01). In this selected group of patients, many of the short-term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable.

Original languageEnglish (US)
Pages (from-to)746-753
Number of pages8
JournalMovement Disorders
Volume21
Issue number6
DOIs
StatePublished - Jun 1 2006

Keywords

  • Deep brain stimulation
  • Outcomes
  • Parkinson's disease
  • Quality of life

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Siderowf, A., Jaggi, J. L., Xie, S. X., Loveland-Jones, C., Leng, L., Hurtig, H., Colcher, A., Stern, M., Chou, K. L., Liang, G., Maccarone, H., Simuni, T., & Baltuch, G. (2006). Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's disease. Movement Disorders, 21(6), 746-753. https://doi.org/10.1002/mds.20786