Long-term effects of FloSeal™ packing after endoscopic sinus surgery

Rakesh K. Chandra*, David B. Conley, G. Kenneth Haines, Robert C. Kern

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Background: A previous study by our group showed increased adhesions and granulation tissue in ethmoid cavities packed with FloSeal (FS) compared with those packed with thrombin-soaked gelatin foam after endoscopic sinus surgery (ESS). That study included 20 patients whose cavities were graded 6-8 weeks postoperatively. The goal of this study was to report long-term follow-up on this cohort. Methods: At least 1 year follow-up was available in 18/20 patients. The number of office procedures required to lyse adhesions during the follow-up period was tabulated also. Pathology was available from one patient who underwent lysis of adhesions on an FS side. The histopathological findings are presented. Results: The mean follow-up period was 21.4 (± 2.3) months, and none of the 18 patients required revision ESS during this interval. The overall incidence of adhesions (p = 0.013) and the number requiring lysis of adhesions (p = 0.046) were both greater in the FS group. During the interval between previous study evaluation (6-8 weeks postop) and last follow-up, five FS sides required a total of seven procedures to lyse adhesions. Silent adhesions were observed in an additional five FS sides. Although asymptomatic adhesions were observed in two thrombin-soaked gelatin sides at last examination, none underwent lysis. Biopsy of an adhesion from a patient packed with FS 25 months earlier revealed incorporated foreign material. Conclusion: FS appears to be associated with scar tissue formation and may be incorporated into recovering mucosa. Use of FS may increase the degree of postoperative care required after EES.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalAmerican Journal of Rhinology
Issue number3
StatePublished - 2005

ASJC Scopus subject areas

  • Otorhinolaryngology


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