Long-term enhancement of K+-evoked release of l-glutamate in entorhinal kindled rats

Changiz Geula; Patrick A. Jarvie; Thomas C. Logan; John T. Slevin

doi:10.1016/0006-8993(88)91528-4

Long-term enhancement of K⁺-evoked release of l-glutamate in entorhinal kindled rats

Changiz Geula, Patrick A. Jarvie, Thomas C. Logan, John T. Slevin^*

^*Corresponding author for this work

Mesulam Center for Cognitive Neurology and Alzheimers Disease

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Kainic acid- and K⁺-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K⁺-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

Original language	English (US)
Pages (from-to)	368-372
Number of pages	5
Journal	Brain research
Volume	442
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)91528-4
State	Published - Mar 1 1988

Funding

The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.

Keywords

Amino acid
Glutamate
Hippocampus
Kainic acid
Kindling
Neurotransmitter release

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(88)91528-4

Cite this

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title = "Long-term enhancement of K+-evoked release of l-glutamate in entorhinal kindled rats",

abstract = "Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.",

keywords = "Amino acid, Glutamate, Hippocampus, Kainic acid, Kindling, Neurotransmitter release",

author = "Changiz Geula and Jarvie, {Patrick A.} and Logan, {Thomas C.} and Slevin, {John T.}",

note = "Funding Information: The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.",

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T1 - Long-term enhancement of K+-evoked release of l-glutamate in entorhinal kindled rats

AU - Geula, Changiz

AU - Jarvie, Patrick A.

AU - Logan, Thomas C.

AU - Slevin, John T.

N1 - Funding Information: The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.

PY - 1988/3/1

Y1 - 1988/3/1

N2 - Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

AB - Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

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