Long-term follow-up of acute retinal necrosis

Beeran Meghpara, Gregory Sulkowski, Muge R. Kesen, Howard H. Tessler, Debra A. Goldstein

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Purpose: The purpose of this study was to report long-term visual outcome of acute retinal necrosis. Methods: Medical records of patients with acute retinal necrosis were reviewed. Results: Thirty-two patients were diagnosed with acute retinal necrosis from 1998 to 2007. Twenty patients (25 eyes) had at least 1 follow-up and available medical records. Intravitreal injections of ganciclovir and/or foscarnet were administered in 11 of 25 eyes. Intravenous and oral antiviral medications were used in 14 of 20 and 19 of 20 patients, respectively. Eleven of 25 eyes had <25% of retina affected, 8 of 25 had 25% to 50% of retina affected, and 6 of 25 had >50% of retina affected. Mean visual acuity at all time points was best when retinitis involved <25% and decreased as area increased. All but 1 eye with >50% involvement experienced decreased vision regardless of treatment. Three of 4 eyes with 25% to 50% involvement that received intravitreal antivirals had an improvement in visual acuity of ≥2 Snellen lines. Five of 25 eyes developed retinal detachment. None of the six eyes treated with prophylactic laser detached. Conclusion: Greater extent of retinitis portends a worse visual prognosis. Although intravitreal treatment did not prevent visual acuity loss in patients with severe disease, patients with moderate disease (25-50% retina involved) did well with intravitreal therapy with most having stable or improved visual acuity. Prophylactic laser decreased the rate of detachment.

Original languageEnglish (US)
Pages (from-to)795-800
Number of pages6
Issue number5
StatePublished - May 1 2010


  • ARN
  • Acute retinal necrosis
  • Herpes
  • Necrotizing herpetic retinitis

ASJC Scopus subject areas

  • Ophthalmology


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