Long-term potentiation as synaptic dialogue

Patricia A. Colley, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

120 Scopus citations


We have proposed a testable model of the physiological and biochemical events underlying LTP that offers the following novel features. 1. (1) The focus is not on a single mechanism or synaptic site, but rather on the integration and interaction of mechanisms occurring on both sides of the synapse. 2. (2) β PKC plays a critical presynaptic role in LTP, while γ PKC functions postsynaptically. 3. (3) These stages can be ordered in a time-delimited sequence of post- then presynaptic molecular events based on the period of effectiveness of inhibitor compounds. 4. (4) The distinction is made between the time when kinase activation occurs and the time when the potentiated response requiring this kinase activation is observed.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalBrain Research Reviews
Issue number1
StatePublished - 1993


  • Hippocampus
  • Long-term potentiation
  • Protein kinase C
  • Transsynaptic signalling

ASJC Scopus subject areas

  • Clinical Neurology
  • General Neuroscience


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