Long-term potentiation in distinct subtypes of hippocampal nonpyramidal neurons

Gianmaria Maccaferri, Chris J. McBain*

*Corresponding author for this work

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

We have investigated NMDA receptor-dependent long-term potentiation (LTP) in distinct subtypes of nonpyramidal neurons of the CA1 hippocampus using induction protocols that permitted the differentiation between a direct form of LTP and plasticity resulting simply from the 'passive propagation' of LTP occurring on CA1 pyramidal neurons. Two types of stratum (st.) oriens/alveus interneurons received passive propagation of synaptic potentiation via the recurrent collaterals of CA1 pyramidal cells, but neither subtype possessed direct plasticity. In st. radiatum, two distinct classes of cells were observed: st. radiatum interneurons that showed neither direct nor propagated forms of synaptic plasticity, and 'giant cells' for which EPSPs were robustly potentiated after a pairing protocol. This potentiation is similar to the LTP described in pyramidal cells, and its induction requires NMDA receptor activation. Thus, a large heterogeneity of synaptic plasticity exists in morphologically distinct neurons and suggests that complex changes in the CA1 network properties will occur after the induction of LTP.

Original languageEnglish (US)
Pages (from-to)5334-5343
Number of pages10
JournalJournal of Neuroscience
Volume16
Issue number17
DOIs
StatePublished - Sep 1 1996

Keywords

  • CA1
  • GABAergic
  • LTP
  • hippocampus
  • interneurons
  • plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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