Long-Term Potentiation (LTP): Mossy Fiber cAMP-Dependent Presynaptic LTP

A. Contractor*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Mossy fiber synapses in the hippocampus are formed by the axons of the granule cells and their postsynaptic targets in the hilar and CA3 regions of the hippocampus. The excitatory synapses formed with the principal pyramidal neurons exhibit a number of unique structural and functional properties, including a distinctive form of long-term potentiation that is expressed in the presynaptic terminal and is dependent on cyclic adenosine monophosphate signaling. Here the current state of our understanding of this form of synaptic plasticity is reviewed.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages4
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • Adenylyl cyclase
  • CAmp
  • Hippacampus
  • LTP
  • Mossy fiber
  • PKA
  • Presynaptic
  • RIMI?
  • Rab3a

ASJC Scopus subject areas

  • Neuroscience(all)


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