Long-term potentiation persistence greater in C57BL/6 than DBA/2 mice: Predicted on basis of protein kinase C levels and learning performance

Shogo Matsuyama, Uk Namgung, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The gamma isoform of protein kinase C (γ-PKC) activity is elevated and learning is superior in the inbred C57BL/6 mouse when compared to the DBA/2 mouse strain. Given the proposed link between PKC and long-term potentiation (LTP) on the one hand and PKC and learning on the other, it was predicted that LTP persistence would be greater in C57BL/6 mouse. When suprathreshold levels of tetanic stimulation were used, similar persistent LTP was observed in both C57BL/6 and DBA/2 strains. However, when tetanus was at threshold, the response in DBA/2 mice decayed to baseline in 30 min, similar to short- term potentiation (STP). Using this same paradigm with C57BL/6 mice, LTP persisted for 4 h, the longest time tested. The time course of the results parallels those observed in rat when phorbol ester, a potent PKC activator, converts STP to LTP. The present findings thus confirm the predicted difference between the two mouse strains. Moreover, the present findings are consistent with a role for γ-PKC in LTP. Since such results call attention to the need for γ-PKC interventive procedures, the relative utility of current PKC inhibitors, null mutants and antisense methods are discussed.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalBrain research
Volume763
Issue number1
DOIs
StatePublished - Jul 18 1997

Keywords

  • C57BL/6 mice
  • DBA/2 mice
  • Hippocampus
  • Long-term potentiation
  • γ-PKC

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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