Long term risk of Wolff-Parkinson-White pattern and syndrome

Susan S. Kim*, Bradley P. Knight

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


For years, conventional wisdom has held that patients with asymptomatic ventricular pre-excitation (asymptomatic WPW or WPW pattern) were at low risk for adverse outcomes. This assumption has been challenged more recently in a number of observational/natural history studies as well as in prospective trials in which patients were more aggressively studied via invasive electrophysiology study (EPS) and more aggressively treated, in some cases, with pre-emptive catheter ablation, despite the lack of symptoms. In sum, the data do not definitively support one approach (early, up-stream EPS and/or ablation) vs. the other (watchful waiting with close monitoring). The most recent pediatric and adult guidelines reflect this ambiguity with a broad spectrum of approaches endorsed.

Original languageEnglish (US)
Pages (from-to)260-268
Number of pages9
JournalTrends in Cardiovascular Medicine
Issue number4
StatePublished - May 2017


  • Asymptomatic
  • Atrial fibrillation
  • Cardiac arrest
  • Catheter ablation
  • Electrophysiology study
  • Sudden death
  • Ventricular fibrillation
  • Ventricular pre-excitation
  • WPW pattern
  • WPW syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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