Long-term visual and anatomical outcomes following anti-VEGF monotherapy for retinal angiomatous proliferation

Tarek S. Hemeida, Pearse A. Keane, Laurie Dustin, Srinivas R. Sadda, Amani A. Fawzi

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Aim: To study the long-term visual and anatomical outcomes of antivascular endothelial growth factor (VEGF) monotherapy for the treatment of patients with retinal angiomatous proliferation (RAP). Methods: Retrospective review of patients who were diagnosed as having AMD and RAP lesions, and who received anti-VEGF injections as the only mode of therapy. Results: 20 eyes (15 patients; nine women, six men) with RAP lesions treated by anti-VEGF were encountered. The mean patient age was 85.8 years (SD±4.54). Nine eyes were treated with intravitreal ranibizumab alone, eight eyes were treated with bevacizumab alone, and three eyes received both drugs. At 1, 3 and 6 months' follow-up the median VA had improved from baseline (20/72) to 20/52 (range: 20/25 to 20/400), 20/45 (range 20/20 to 20/400), and 20/56 (range 20/20 to 20/400), respectively, (p>0.001, p=0.001 and p=0.05, respectively). At the 24-month follow-up, the improvement in VA, defined as a halving of the visual angle, occurred in 37.5% of the cases. Conclusions: Anti-VEGF monotherapy represents a useful treatment option for RAP, with stable or improved visual acuity in 62.5% of patients at 2 years. 25% of eyes required only a single injection, but in most cases (75%) repeated treatments were required, highlighting the need for long term follow-up. Although, in this small study, the results for visual improvement were not statistically significant beyond 3 months, our findings warrant further large-scale investigation.

Original languageEnglish (US)
Pages (from-to)701-705
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number6
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Long-term visual and anatomical outcomes following anti-VEGF monotherapy for retinal angiomatous proliferation'. Together they form a unique fingerprint.

Cite this