Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

L. M. Chahine; S. X. Xie; T. Simuni; B. Tran; R. Postuma; A. Amara; W. H. Oertel; A. Iranzo; C. Scordia; M. Fullard; C. Linder; R. Purri; A. Darin; L. Rennert; A. Videnovic; P. Del Riva; D. Weintraub

doi:10.1016/j.parkreldis.2016.03.006

Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

L. M. Chahine^*, S. X. Xie, T. Simuni, B. Tran, R. Postuma, A. Amara, W. H. Oertel, A. Iranzo, C. Scordia, M. Fullard, C. Linder, R. Purri, A. Darin, L. Rennert, A. Videnovic, P. Del Riva, D. Weintraub

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Introduction Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. Methods Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ ≥ 6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. Results The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = −0.34, 95%CI −0.54, −0.13, p < 0.001), Symbol Digit Modalities Test (β = −0.69, 95%CI −1.3, −0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = −0.21, 95%CI −0.41, −0.013, p = 0.037). Conclusions Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.

Original language	English (US)
Pages (from-to)	102-106
Number of pages	5
Journal	Parkinsonism and Related Disorders
Volume	27
DOIs	https://doi.org/10.1016/j.parkreldis.2016.03.006
State	Published - 2016

Funding

Aleksander Videnovic receives research funding from NIH K23 N70S080912 . Sharon Xie receives funding support from NIH AG10124 and NIH NS053488 . Tanya Simuni has received consulting fees as a speaker and/or consultant from GE Medical, TEVA. Acadia, Abbvie, Eli Lilly, Harbor, IMPAX, Lundbeck, Merz, Inc., Navidea, Pfizer, UCB Pharma US World Meds. The National Parkinson Foundation has provided Dr. Simuni with research funding for studies and she is a consultant for the foundation. Dr. Simuni has received research funding from TEVA , Auspex , Biotie , and Civitas . The NIH and the Michael J. Fox Foundation have provided research funding. Ron Postuma received grants from the Fonds de la Recherche en Sante Quebec , the Canadian Institute of Health Research , the Parkinson Society , the Weston-Garfield Foundation , and the Webster Foundation , as well as funding for consultancy from Biotie and speaker fees from Novartis Canada and Teva Neurosciences. Lior Rennert receives funding support from NIH T32MH065218 . Daniel Weintraub has received research funding or support from Michael J. Fox Foundation for Parkinson's Research , National Institutes of Health , Novartis Pharmaceuticals , Department of Veterans Affairs , Avid Radiopharmaceuticals , and Alzheimer's Disease Cooperative Study ; honoraria from AbbVie, Biotie, Teva Pharmaceuticals, Otsuka, UCB, Clintrex LLC, and the CHDI Foundation; license fee payments from the University of Pennsylvania for the QUIP and QUIP-RS; royalties from Wolters Kluweland; and fees for legal consultation for lawsuit related to antipsychotic prescribing in a patient with Parkinson's disease. Wolfgang H Oertel is Hertie Senior Research Professor of the Charitable Hertie Foundation, Frankfurt/Main, Germany. He received research grants form the German Research Foundation , International Parkinson Foundations , the Michael J Fox Foundation and the EU- Research Program Horizon 2020 (JPND). He is consultant of the Novartis Foundation. He received consulting fees as a speaker and/or consultant from AbbVie, Desitin, GE Health, Mundipharma and UCB- Amy W. Amara, MD, PhD receives research funding from NIH K23NS080912 and the Michael J. Fox Foundation and has served as an investigator for studies funded by Abbvie .

Keywords

Cognition
Dementia
REM sleep behavior disorder

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2016.03.006

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Chahine, L. M., Xie, S. X., Simuni, T., Tran, B., Postuma, R., Amara, A., Oertel, W. H., Iranzo, A., Scordia, C., Fullard, M., Linder, C., Purri, R., Darin, A., Rennert, L., Videnovic, A., Del Riva, P., & Weintraub, D. (2016). Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder. Parkinsonism and Related Disorders, 27, 102-106. https://doi.org/10.1016/j.parkreldis.2016.03.006

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title = "Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder",

abstract = "Introduction Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. Methods Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ ≥ 6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. Results The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = −0.34, 95%CI −0.54, −0.13, p < 0.001), Symbol Digit Modalities Test (β = −0.69, 95%CI −1.3, −0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = −0.21, 95%CI −0.41, −0.013, p = 0.037). Conclusions Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.",

keywords = "Cognition, Dementia, REM sleep behavior disorder",

author = "Chahine, {L. M.} and Xie, {S. X.} and T. Simuni and B. Tran and R. Postuma and A. Amara and Oertel, {W. H.} and A. Iranzo and C. Scordia and M. Fullard and C. Linder and R. Purri and A. Darin and L. Rennert and A. Videnovic and {Del Riva}, P. and D. Weintraub",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2016",

doi = "10.1016/j.parkreldis.2016.03.006",

language = "English (US)",

volume = "27",

pages = "102--106",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

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Chahine, LM, Xie, SX, Simuni, T, Tran, B, Postuma, R, Amara, A, Oertel, WH, Iranzo, A, Scordia, C, Fullard, M, Linder, C, Purri, R, Darin, A, Rennert, L, Videnovic, A, Del Riva, P & Weintraub, D 2016, 'Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder', Parkinsonism and Related Disorders, vol. 27, pp. 102-106. https://doi.org/10.1016/j.parkreldis.2016.03.006

TY - JOUR

T1 - Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

AU - Chahine, L. M.

AU - Xie, S. X.

AU - Simuni, T.

AU - Tran, B.

AU - Postuma, R.

AU - Amara, A.

AU - Oertel, W. H.

AU - Iranzo, A.

AU - Scordia, C.

AU - Fullard, M.

AU - Linder, C.

AU - Purri, R.

AU - Darin, A.

AU - Rennert, L.

AU - Videnovic, A.

AU - Del Riva, P.

AU - Weintraub, D.

PY - 2016

Y1 - 2016

N2 - Introduction Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. Methods Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ ≥ 6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. Results The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = −0.34, 95%CI −0.54, −0.13, p < 0.001), Symbol Digit Modalities Test (β = −0.69, 95%CI −1.3, −0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = −0.21, 95%CI −0.41, −0.013, p = 0.037). Conclusions Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.

AB - Introduction Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. Methods Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ ≥ 6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. Results The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = −0.34, 95%CI −0.54, −0.13, p < 0.001), Symbol Digit Modalities Test (β = −0.69, 95%CI −1.3, −0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = −0.21, 95%CI −0.41, −0.013, p = 0.037). Conclusions Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.

KW - Cognition

KW - Dementia

KW - REM sleep behavior disorder

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SN - 1353-8020

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JO - Parkinsonism and Related Disorders

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ER -

Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

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