Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

L. M. Chahine*, S. X. Xie, T. Simuni, B. Tran, R. Postuma, A. Amara, W. H. Oertel, A. Iranzo, C. Scordia, M. Fullard, C. Linder, R. Purri, A. Darin, L. Rennert, A. Videnovic, P. Del Riva, D. Weintraub

*Corresponding author for this work

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Introduction Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. Methods Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ ≥ 6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. Results The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = −0.34, 95%CI −0.54, −0.13, p < 0.001), Symbol Digit Modalities Test (β = −0.69, 95%CI −1.3, −0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = −0.21, 95%CI −0.41, −0.013, p = 0.037). Conclusions Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalParkinsonism and Related Disorders
Volume27
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cognition
  • Dementia
  • REM sleep behavior disorder

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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    Chahine, L. M., Xie, S. X., Simuni, T., Tran, B., Postuma, R., Amara, A., Oertel, W. H., Iranzo, A., Scordia, C., Fullard, M., Linder, C., Purri, R., Darin, A., Rennert, L., Videnovic, A., Del Riva, P., & Weintraub, D. (2016). Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder. Parkinsonism and Related Disorders, 27, 102-106. https://doi.org/10.1016/j.parkreldis.2016.03.006