Longitudinal changes in white matter following ischemic stroke: A three-year follow-up study

Changsheng Wang*, Glenn T. Stebbins, David L. Nyenhuis, Leyla deToledo-Morrell, Sally Freels, Eugenia Gencheva, Laura Pedelty, Kumar Sripathirathan, Michael E. Moseley, David A. Turner, John D.E. Gabrieli, Philip B. Gorelick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Information on longitudinal changes in white matter after stroke is limited. The aim of the present study was to quantitatively investigate longitudinal changes in the microstructural integrity of non-lesioned white matter at 1-3 years following ischemic stroke. In a sample of 80 ischemic stroke patients, we obtained diffusion tensor imaging (DTI) measures of fractional anisotropy (FA), an apparent measure of white matter integrity, in radiologically normal-appearing white matter at baseline and 3 years of follow-up. Mixed model regression analysis results showed a significant improvement in FA from baseline during the first 2 years of follow-up that stabilized by the third year of follow-up. These results demonstrate a long-term improvement in apparent white matter integrity following ischemic stroke that continues, at least, into the second year following the insult.

Original languageEnglish (US)
Pages (from-to)1827-1833
Number of pages7
JournalNeurobiology of Aging
Issue number12
StatePublished - Dec 2006


  • Cerebral ischemia
  • DTI
  • Longitudinal survey
  • MRI

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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