Longitudinal changes on optical coherence tomography angiography in retinal vein occlusion

Swetapadma Tripathy, Hong Gam Le, Maria Vittoria Cicinelli, Manjot K. Gill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion (p = 0.07 and p = 0.04) and last visit (p = 0.002 and p < 0.001). VD, AFI, and VLD did not change over time, while FAZ area increased in RVO eyes (+0.016 ± 0.024 mm2, p = 0.04). AFI correlated with duration of disease (r = 0.63, p = 0.02). Visual acuity was inversely related to VD and VLD over the follow-up. Conclusions: OCTA parameters remained stable with sustained anti-VEGF treatment in RVO, while changes in the FAZ area may suggest capillary remodeling after RVO.

Original languageEnglish (US)
Article number1423
JournalJournal of Clinical Medicine
Volume10
Issue number7
DOIs
StatePublished - Apr 1 2021

Keywords

  • Anti-vascular endothelial growth factors
  • Optical coherence tomography angiography
  • Retinal vein occlusion
  • Vessel density

ASJC Scopus subject areas

  • General Medicine

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