Longitudinal trajectory of vitamin D status from birth to early childhood in The development of food sensitization

Xin Liu*, Lester Arguelles, Ying Zhou, Guoying Wang, Qi Chen, Hui Ju Tsai, Xiumei Hong, Rong Liu, Heather E. Price, Colleen Pearson, Stephanie Apollon, Natalie Cruz, Robert Schleimer, Craig B. Langman, Jacqueline A. Pongracic, Xiaobin Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Background:Increasing evidence supports The immunomodulatory effect of vitamin D on allergic diseases. The combined role of prenatal and postnatal vitamin D status in The development of food sensitization (FS) and food allergy remains understudied.Methods:Plasma 25-hydroxyvitamin D (25(OH)D) levels of 460 children in The Boston Birth Cohort (BBC) were measured at birth and early childhood, and The subjects were genotyped for rs2243250 (C-590T) in The IL4 gene. We defined FS as specific IgE levels of ≥0.35 kUA/l to any of eight common food allergens; we defined persistently low vitamin D status as cord blood 25(OH)D <11 ng/ml and postnatal 25(OH)D <30 ng/ml.Results:We observed a moderate correlation between cord blood 25(OH)D at birth and venous blood 25(OH)D measured at 2-3 y (r = 0.63), but a weak correlation at <1 y (r = 0.28). There was no association between low vitamin D status and FS at any single time point alone. However, in combination, persistence of low vitamin D status at birth and in early childhood increased The risk of FS (odds ratio (OR) = 2.03, 95% confidence interval (CI): 1.02-4.04), particularly among children carrying The C allele of rs2243250 (OR = 3.23, 95% CI: 1.37-7.60).Conclusion: Prenatal and early postnatal vitamin D levels, along with individual genetic susceptibility, should be considered in assessing The role of vitamin D in The development of FS and food allergy.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalPediatric research
Issue number3
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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